The loss of regenerative capacity is the most dramatic age-associated alteration in the liver.
Although this phenomenon was reported over 50 years ago, the molecular basis for the loss …

Populations in developed countries continue to grow older and an understanding of the
ageing process to allow healthy ageing carries important medical implications. Older …

Inactivation of the Caenorhabditis elegans gene clk-1, which is required for ubiquinone
biosynthesis, increases lifespan by an insulin signaling-independent mechanism. We find …

The liver is capable of completely regenerating itself in response to injury and after partial
hepatectomy. In liver of old animals, the proliferative response is dramatically reduced, the …

The liver has an intrinsic capacity to regenerate in response to injury or surgical resection.
Nevertheless, circumstances in which hepatocytes are unresponsive to proliferative signals …

The proportion of elderly people in the world population is constantly increasing. With age,
the risk of numerous chronic diseases and their complications also rises. Research on the …

Backgrounds & Aims: An increased risk of hepatitis C virus (HCV)-related cirrhosis is
associated with hepatic steatosis, older age, and high alcohol consumption, which could be …

Cellular senescence is an irreversible cell cycle arrest implemented by the cell as a result of
stressful insults. Characterized by phenotypic alterations, including secretome changes and …

Aging increases the incidence of chronic liver disease (CLD), worsens its prognosis, and
represents the predominant risk factor for its development at all different stages. The hepatic …

The regenerative capacity of the liver after resection is reduced with aging. Recent studies
on rodents revealed that both intracellular and extracellular factors are involved in the …