The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving
30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of …

The craniofacial skeletal structures that comprise the human head develop from multiple
tissues that converge to form the bones and cartilage of the face. Because of their complex …

Defects in patterning during human embryonic development frequently result in craniofacial
abnormalities. The gene regulatory programs that build the craniofacial complex are likely …

Spatially resolved transcriptomic techniques allow the characterization of spatial
organization of cells in tissues, which revolutionize the studies of tissue function and disease …

The advent of next-generation sequencing has introduced new opportunities in analyzing
gene expression data. Research in systems biology has taken advantage of these …

The mammalian lip and primary palate form when coordinated growth and morphogenesis
bring the nasal and maxillary processes into contact, and the epithelia co-mingle, remodel …

The RNA-editing protein ADAR is essential for early development in the mouse. Genetic
evidence suggests that A to I editing marks endogenous RNAs as 'self'. Today, different Adar …

For well over half of the 150 years since the discovery of the neural crest, the special ability
of these cells to function as a source of species‐specific pattern has been clearly …

During mammalian embryonic development, a single fertilized egg cell will proliferate and
differentiate into all the cell lineages and cell types that eventually form the adult organism …

Precise control of jaw length during development is crucial for proper form and function.
Previously we have shown that in birds, neural crest mesenchyme (NCM) confers species …