Functional enrichment analysis is pivotal for interpreting high-throughput omics data in life
science. It is crucial for this type of tool to use the latest annotation databases for as many …

Background We recently identified two robust ovarian cancer subtypes, defined by the
expression of genes involved in angiogenesis, with significant differences in clinical …

Background Abnormal pre-mRNA splicing regulation is common in cancer, but the effects of
chemotherapy on this process remain unclear. Methods To evaluate the effect of …

Immunogenic cell death (ICD) refers to a unique form of cell death that activates an adaptive
immune response against dead-cell-associated antigens. Accumulating evidence indicates …

We have previously showed that platinum drugs up-regulate SSAT and SMO and down-
regulate ODC and SAMDC in the polyamine pathway. Several studies including our own …

Abstract Background Cerebral cavernous malformations (CCMs) is a neurological disorder
that causes enlarged intracranial capillaries in the brain, leading to an increased risk of …

Cerebral cavernous malformations (CCMs) are a neurological disorder characterized by
enlarged intracranial capillaries in the brain, increasing the susceptibility to hemorrhagic …

The dose response curve is the gold standard for measuring the effect of a drug treatment,
but is rarely used in genomic scale transcriptional profiling due to perceived obstacles of …

Background One method to understand and evaluate an experiment that produces a large
set of genes, such as a gene expression microarray analysis, is to identify …

Background Nanomaterials are being manufactured on a commercial scale for use in
medical, diagnostic, energy, component and communications industries. However, concerns …