Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …

The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …

Five versions of the Chlamydomonas reinhardtii reference genome have been produced
over the last two decades. Here we present version 6, bringing significant advances in …

The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …

This article reviews the currently used therapeutic strategies to target DNA replication stress
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …

Bloom syndrome protein (BLM) is a conserved RecQ family helicase involved in the
maintenance of genome stability. BLM has been widely recognized as a genome “caretaker” …

The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR)
during their course of treatment, yet the efficacy of these therapies is tempered by DNA …

Homologous recombination (HR) is a key DNA damage repair pathway that is tightly
adjusted to the state of a cell. A central regulator of homologous recombination is the …

RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is
characterized by the early onset of aging-associated diseases, including shortening stature …