G-quadruplex DNA: a novel target for drug design
FY Teng, ZZ Jiang, M Guo, XZ Tan, F Chen… - Cellular and Molecular …, 2021 - Springer
Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
[HTML][HTML] Cyclin-dependent kinases in DNA damage response
The cyclin-dependent kinase (CDK) family plays a critical role in a variety of signaling
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …
pathways that regulate transcription and cell-cycle progression. Recently, the role of CDKs …
The Chlamydomonas Genome Project, version 6: Reference assemblies for mating-type plus and minus strains reveal extensive structural mutation in the laboratory
Five versions of the Chlamydomonas reinhardtii reference genome have been produced
over the last two decades. Here we present version 6, bringing significant advances in …
over the last two decades. Here we present version 6, bringing significant advances in …
Resistance to DNA repair inhibitors in cancer
The DNA damage response (DDR) represents a complex network of proteins which detect
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …
and repair DNA damage, thereby maintaining the integrity of the genome and preventing the …
Therapeutic targeting of DNA replication stress in cancer
L Gu, RJ Hickey, LH Malkas - Genes, 2023 - mdpi.com
This article reviews the currently used therapeutic strategies to target DNA replication stress
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …
for cancer treatment in the clinic, highlighting their effectiveness and limitations due to …
Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates
T Wang, J Hu, Y Li, L Bi, L Guo, X Jia… - Angewandte Chemie …, 2022 - Wiley Online Library
Bloom syndrome protein (BLM) is a conserved RecQ family helicase involved in the
maintenance of genome stability. BLM has been widely recognized as a genome “caretaker” …
maintenance of genome stability. BLM has been widely recognized as a genome “caretaker” …
Recent advances in the development of non-PIKKs targeting small molecule inhibitors of DNA double-strand break repair
JM Kelm, A Samarbakhsh, A Pillai… - Frontiers in …, 2022 - frontiersin.org
The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR)
during their course of treatment, yet the efficacy of these therapies is tempered by DNA …
during their course of treatment, yet the efficacy of these therapies is tempered by DNA …
KNO1‐mediated autophagic degradation of the Bloom syndrome complex component RMI1 promotes homologous recombination
P Chen, N De Winne, G De Jaeger, M Ito… - The EMBO …, 2023 - embopress.org
Homologous recombination (HR) is a key DNA damage repair pathway that is tightly
adjusted to the state of a cell. A central regulator of homologous recombination is the …
adjusted to the state of a cell. A central regulator of homologous recombination is the …
Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication
M Ito, Y Fujita, A Shinohara - DNA repair, 2023 - Elsevier
RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …
Research on werner syndrome: Trends from past to present and future prospects
K Tsuge, A Shimamoto - Genes, 2022 - mdpi.com
A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is
characterized by the early onset of aging-associated diseases, including shortening stature …
characterized by the early onset of aging-associated diseases, including shortening stature …