Bacteria can rapidly and reversibly respond to changing environments via complex
transcriptional and post-transcriptional regulatory mechanisms. Many of these adaptations …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Regulated proteolysis is a vital process that affects all living things. Bacteria use energy-
dependent AAA+ proteases to power degradation of misfolded and native regulatory …

In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in
proteostasis. The disruption of the ClpP function has been shown to influence the infectivity …

The caseinolytic protease proteolytic subunit (ClpP) is a serine protease playing an
important role in proteostasis of eukaryotic organelles and prokaryotic cells. Alteration of …

ClpP is a highly conserved serine protease that is a critical enzyme in maintaining protein
homeostasis and is an important drug target in pathogenic bacteria and various cancers. In …

The general stress response (GSR) is a widespread strategy developed by bacteria to adapt
and respond to their changing environments. The GSR is induced by one or multiple …

Microorganisms live in fluctuating environments, requiring stress response pathways to
resist environmental insults and stress. These pathways dynamically monitor cellular status …

Regulated protein degradation is essential. The timed destruction of crucial proteins by the
ClpXP protease drives cell-cycle progression in the bacterium Caulobacter crescentus …

In enterobacteria such as Escherichia coli, the general stress response is mediated by σ s,
the stationary phase dissociable promoter specificity subunit of RNA polymerase. σ s is …