[HTML][HTML] The blood-brain barrier in aging and neurodegeneration

EG Knox, MR Aburto, G Clarke, JF Cryan… - Molecular …, 2022 - nature.com
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

[HTML][HTML] A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

H Kadry, B Noorani, L Cucullo - Fluids and Barriers of the CNS, 2020 - Springer
The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms

X Huang, B Hussain, J Chang - CNS neuroscience & …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

[HTML][HTML] Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease

Y Inoue, F Shue, G Bu, T Kanekiyo - Molecular neurodegeneration, 2023 - Springer
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

The blood–tumour barrier in cancer biology and therapy

PS Steeg - Nature Reviews Clinical Oncology, 2021 - nature.com
The protective blood–brain barrier has a major role in ensuring normal brain function by
severely limiting and tightly controlling the ingress of substances into the brain from the …

The blood–brain barrier in health and disease: Important unanswered questions

CP Profaci, RN Munji, RS Pulido… - Journal of Experimental …, 2020 - rupress.org
The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

[HTML][HTML] Blood-brain barrier: from physiology to disease and back

MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

[HTML][HTML] Blood–brain barrier breakdown: an emerging biomarker of cognitive impairment in normal aging and dementia

B Hussain, C Fang, J Chang - Frontiers in neuroscience, 2021 - frontiersin.org
The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

The role of brain vasculature in neurodegenerative disorders

MD Sweeney, K Kisler, A Montagne, AW Toga… - Nature …, 2018 - nature.com
Adequate supply of blood and structural and functional integrity of blood vessels are key to
normal brain functioning. On the other hand, cerebral blood flow shortfalls and blood–brain …

[HTML][HTML] Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …