Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and
proliferation. Many studies have shown that Src plays multiple roles in macrophage …

Double-stranded (ds) RNA has diverse roles in host defense and disease prevention.
dsRNA, produced by viral replication, elicits strong antiviral responses in host; similar …

Viral infections frequently induce acute and chronic inflammatory diseases, yet the
contribution of the innate immune response to a detrimental host response remains poorly …

The transcription factor GATA-3 is expressed and required for differentiation and function
throughout the T lymphocyte lineage. Despite evidence it may also be expressed in …

The heat‐shock protein 27 (HSP27) is up‐regulated in tumor cells and released in their
microenvironment. Here, we show that extracellular HSP27 has a proangiogenic effect …

There is a wealth of knowledge about how different Ser/Thr protein kinases participate in
Toll-like receptor (TLR) signaling. In many cases, we know the identities of the Ser/Thr …

Acute infection is implicated as a trigger for chronic inflammatory disease, but the full basis
for this switch is uncertain. In this study, we examine this issue using a mouse model of …

Tissue regeneration and functional restoration after injury are considered as stem-and
progenitor-cell-driven processes. In the central nervous system, stem cell-driven repair is …

Toll-like receptors serve a central role in innate immunity, but they can also modulate cell
function in various non-immune cell types including endothelial cells. Endothelial cells are …

Activated microglial cells are present in dengue virus (DENV)-infected brains; however, the
possible effects of DENV on microglia remain unclear. Here, we demonstrated DENV …