Immune biomarkers for diagnosis and treatment monitoring of tuberculosis: current developments and future prospects
Tuberculosis (TB) treatment monitoring is paramount to clinical decision-making and the
host biomarkers appears to play a significant role. The currently available diagnostic …
host biomarkers appears to play a significant role. The currently available diagnostic …
Precision medicine in distinct heart failure phenotypes: focus on clinical epigenetics
Heart failure (HF) management is challenging due to high clinical heterogeneity of this
disease which makes patients responding differently to evidence-based standard therapy …
disease which makes patients responding differently to evidence-based standard therapy …
Distinct epigenomic features in end-stage failing human hearts
Background—The epigenome refers to marks on the genome, including DNA methylation
and histone modifications, that regulate the expression of underlying genes. A consistent …
and histone modifications, that regulate the expression of underlying genes. A consistent …
Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I
M Kruse, E Schulze-Bahr, V Corfield… - The Journal of …, 2009 - Am Soc Clin Investig
Progressive familial heart block type I (PFHBI) is a progressive cardiac bundle branch
disease in the His-Purkinje system that exhibits autosomal-dominant inheritance. In 3 …
disease in the His-Purkinje system that exhibits autosomal-dominant inheritance. In 3 …
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support
Background—Much has been learned about transcriptional control of cardiac gene
expression in clinical and experimental congestive heart failure (CHF), but less is known …
expression in clinical and experimental congestive heart failure (CHF), but less is known …
Differential DNA methylation correlates with differential expression of angiogenic factors in human heart failure
Epigenetic mechanisms such as microRNA and histone modification are crucially
responsible for dysregulated gene expression in heart failure. In contrast, the role of DNA …
responsible for dysregulated gene expression in heart failure. In contrast, the role of DNA …
[HTML][HTML] DNA methylation reprograms cardiac metabolic gene expression in end-stage human heart failure
Heart failure (HF) is a leading cause of morbidity and mortality in the United States and
worldwide. As a multifactorial syndrome with unpredictable clinical outcomes, identifying the …
worldwide. As a multifactorial syndrome with unpredictable clinical outcomes, identifying the …
Gene expression profiling reveals potential prognostic biomarkers associated with the progression of heart failure
Background Heart failure (HF) is the most common cause of morbidity and mortality in
developed countries. Here, we identify biologically relevant transcripts that are significantly …
developed countries. Here, we identify biologically relevant transcripts that are significantly …
Heart failure–associated changes in RNA splicing of sarcomere genes
Background—Alternative mRNA splicing is an important mechanism for regulation of gene
expression. Altered mRNA splicing occurs in association with several types of cancer, and a …
expression. Altered mRNA splicing occurs in association with several types of cancer, and a …
Update on myocarditis–what we know so far and where we may be heading
A Rroku, J Kottwitz, B Heidecker - European Heart Journal Acute …, 2021 - academic.oup.com
Myocarditis is defined as an inflammatory infiltration of the myocardium with associated
necrosis and/or degeneration, frequently resulting from different infectious or non-infectious …
necrosis and/or degeneration, frequently resulting from different infectious or non-infectious …