Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen,
the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53 …

Whitehead Institute for Biomedical Research Massachusetts Institute of Technology
Cambridge, Massachusetts 02142 pRB, the product of the retinoblastoma tumor suppressor …

The Rb protein is a tumor suppressor, which plays a pivotal role in the negative control of the
cell cycle and in tumor progression. It has been shown that Rb protein (pRb) is responsible …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

Key molecular lesions in colorectal and other cancers cause β-catenin-dependent
transactivation of T cell factor (Tcf)-dependent genes. Disruption of this signal represents an …

The retinoblastoma susceptibility gene (RB) product, the retinoblastoma protein (pRb),
functions as a regulator of cell proliferation. Introduction of the RB gene into SAOS-2 …

The cellular transcription factor E2F, previously identified as a component of early
adenovirus transcription, has now been shown to be important in cell proliferation control …

SEVERAL lines of evidence implicate the E2F transcription factor as an important
component of cell proliferation control. First, E2F binding sites are found in the promoters of …

Murine Dtypecyclinsassociate with a catalytic subunit (p34PSK. J7 with properties distinct
from known cyclindependent kinases (cdks). Mouse p34psK. J3 shows less than 50% amino …

We have previously defined the promoter elements, sites IIa and IIb, in the rice proliferating
cell nuclear antigen (PCNA) gene that are essential for meristematic tissue-specific …