Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca2+] i).
Normal function requires that [Ca2+] i be sufficiently high in systole and low in diastole …

Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the
most important. It is crucial to the very process that enables the chambers of the heart to …

Myocardial infarction is one of the primary causes of mortality in patients with coronary heart
disease worldwide. Early treatment of acute myocardial infarction restores blood supply of …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

The aim of this work was to investigate whether beat-to-beat alternation in the amplitude of
the systolic Ca2+ transient (Ca2+ alternans) is due to changes of sarcoplasmic reticulum …

Abstract Intracellular [Na+]([Na+] i) is regulated in cardiac myocytes by a balance of Na+
influx and efflux mechanisms. In the normal cell there is a large steady state electrochemical …

The control of intracellular calcium is central to regulation of contractile force in cardiac
muscle. This review illustrates how analysis of the control of calcium requires an integrated …

Abstract Increased Na/Ca exchange (NCX) expression may be part of the genetic
reprogramming in cardiac remodeling. In this review we address the following questions:(1) …