▪ Abstract Although the force fields and interaction energies that control protein behavior can
be inferred indirectly from equilibrium and kinetic measurements, recent developments have …

This chapter presents an introduction to the kinetic analysis of SPR biosensor data for the
determination of affinity and kinetic rate constants of biomolecular interactions between an …

We report molecular dynamics simulations that induce, over periods of 40–500 ps, the
unbinding of biotin from avidin by means of external harmonic forces with force constants …

The influence of mass transport on ligand binding to receptor immobilized in a polymer
matrix, as detected with an evanescent wave biosensor, was investigated. A one …

Microfluidics are emerging as a promising technology for miniaturizing biological assays for
applications in diagnostics and research in life sciences because they enable the parallel …

We describe a solution-phase sensor of lipid-protein binding based on localized surface
plasmon resonance (LSPR) of silver nanocubes. When silica-coated nanocubes are mixed …

Conditions for which a ligand reversibly bound to a cell surface dissociates and then rebinds
to the surface have been theoretically examined. The coupled differential equations that …

Many important cellular processes are regulated by reaction-diffusion (RD) of molecules that
takes place both in the cytoplasm and on the membrane. To model and analyze such …

Many techniques rely on the binding activity of surface-immobilized proteins, including
antibody-based affinity biosensors for the detection of analytes, immunoassays, protein …

This work reviews both the theory and experimental measurements of the fundamental
forces that control protein solution behavior. In addition to the Derjaguin–Landau–Verwey …