Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Obesity, a major risk factor for the development of diabetes mellitus, cardiovascular diseases
and certain types of cancer, arises from a chronic positive energy balance that is often due to …

Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic
feeding circuits. These non-neuronal cells are crucial in determining the functional …

Liraglutide, an anti-diabetic drug and agonist of the glucagon-like peptide one receptor
(GLP1R), has recently been approved to treat obesity in individuals with or without type 2 …

The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

Early-life determinants are thought to be a major factor in the rapid increase of obesity.
However, while maternal nutrition has been extensively studied, the effects of breastfeeding …

Under physiological conditions, the brain consumes over 20% of the whole body energy
supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries …

Communication between the periphery and the brain is key for maintaining energy
homeostasis. To do so, peripheral signals from the circulation reach the brain via the …

Ghrelin, an acylated peptide hormone of 28 amino acids, is an endogenous ligand of the
released growth hormone secretagogue receptor (GHSR). Ghrelin has been isolated from …