Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …

In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Aneurysmal bone cyst (ABC) is a locally aggressive osseous lesion that typically occurs
during the first two decades of life. ABC was regarded historically as a nonneoplastic …

Bone, as well as lung and liver, is one of the most preferential metastatic target sites for
cancers including breast, prostate, and lung cancers. Although the precise molecular …

Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a
key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell …

Background & Aims Pancreatic ductal adenocarcinomas (PDACs) are characterized by
fibrosis and an abundance of cancer-associated fibroblasts (CAFs). We investigated …

Tumor cells undergo epithelial-to-mesenchymal transition (EMT) to convert from a benign to
a malignant phenotype. Our recent focus has been signaling pathways that promote EMT in …

We have previously shown that N-cadherin expression is associated with tumor invasion,
and that some cancer cells respond to specific extracellular matrix molecules by up …

Background Early luminal breast cancer (BC) represents 70% of newly diagnosed BC
cases. Among them, small (under 2 cm) BC without lymph node metastasis (classified as …