Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is
characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads …

In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …

Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the
autophagic degradation of ferritin (“ferritinophagy”), the cytosolic iron storage complex …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Although ferroptosis is an iron-dependent cell death mechanism involved in the
development of some severe diseases (eg, Parkinsonian syndrome, stroke and tumours) …

Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …

BACKGROUND: Ferroptosis is a recently discovered form of iron-dependent nonapoptotic
cell death. It is characterized by loss of the activity of the lipid repair enzyme, glutathione …