The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …

Neuronal migration is a fundamental process in central nervous system (CNS) development.
The assembly of functioning neuronal circuits relies on neuronal migration occurring in the …

Brain function relies on the generation of a large variety of morphologically and functionally
diverse, but specific, neuronal synapses. Here we show that, in mice, the initial formation of …

Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive
difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially …

The Golgi apparatus lies at the heart of the secretory pathway where it is required for
secretory trafficking and cargo modification. Disruption of Golgi architecture and function has …

In the ongoing process of uncovering molecular abnormalities in neurodegenerative
diseases characterized by toxic protein aggregates, nucleo-cytoplasmic transport defects …

Cerebellar development has a remarkably protracted morphogenetic timeline that is
coordinated by multiple cell types. Here, we discuss the intriguing cellular consequences of …

Background Fetal alcohol exposure affects 1 in 100 children making it the leading cause of
mental retardation in the US. It has long been known that alcohol affects cerebellum …

Purkinje cell activity is essential for controlling motor behavior. During motor behavior
Purkinje cells fire two types of action potentials: simple spikes that are generated intrinsically …