Understanding the neurotrophic virus mechanisms and their potential effect on systemic lupus erythematosus development

FR Uribe, VPI González, AM Kalergis, JA Soto… - Brain Sciences, 2024 - mdpi.com
Central nervous system (CNS) pathologies are a public health concern, with viral infections
one of their principal causes. These viruses are known as neurotropic pathogens …

Exploration of the Noncoding Genome for Human-Specific Therapeutic Targets—Recent Insights at Molecular and Cellular Level

W Poller, S Sahoo, R Hajjar, U Landmesser… - Cells, 2023 - mdpi.com
While it is well known that 98–99% of the human genome does not encode proteins, but are
nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs …

Understanding the immune-endocrine effects of vitamin D in SARS-CoV-2 Infection: A role in protecting against neurodamage

E Gotelli, S Soldano, E Hysa, A Casabella… - …, 2023 - karger.com
Calcitriol and hydroxyderivatives of lumisterol and tachisterol are secosteroid hormones with
immunomodulatory and anti-inflammatory properties. Since the beginning of the COVID-19 …

Neuroproteomic Analysis after SARS-CoV-2 Infection Reveals Overrepresented Neurodegeneration Pathways and Disrupted Metabolic Pathways

I Basak, R Harfoot, JE Palmer, A Kumar… - Biomolecules, 2023 - mdpi.com
Besides respiratory illness, SARS-CoV-2, the causative agent of COVID-19, leads to
neurological symptoms. The molecular mechanisms leading to neuropathology after SARS …

SARS-CoV-2 RNA persists in the central nervous system of non-human primates despite clinical recovery

H Li, KA McLaurin, CF Mactutus, J Rappaport… - Molecular …, 2023 - Springer
The post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection is a multisystemic condition characterized by the persistence or emergence of …

In-vitro and in-vivo assessment of nirmatrelvir penetration into CSF, central nervous system cells, tissues, and peripheral blood mononuclear cells

SN Avedissian, JR Malik, AT Podany, M Neely… - Scientific reports, 2024 - nature.com
Three years after SARS-CoV-2 emerged as a global infectious threat, the virus has become
endemic. The neurological complications such as depression, anxiety, and other CNS …

New insights into the pathogenesis of SARS-CoV-2 during and after the COVID-19 pandemic

JJ Carvajal, V García-Castillo, SV Cuellar… - Frontiers in …, 2024 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the
respiratory distress condition known as COVID-19. This disease broadly affects several …

Modulation of Paracellular Permeability in SARS-CoV-2 Blood-to-Brain Transcytosis

TE Martinez, K Mayilsamy, SS Mohapatra, S Mohapatra - Viruses, 2024 - mdpi.com
SARS-CoV-2 primarily infects the lungs via the ACE2 receptor but also other organs
including the kidneys, the gastrointestinal tract, the heart, and the skin. SARS-CoV-2 also …

Exploring the Complexities of Long COVID

J Donald, SE Bilasy, C Yang, A El-Shamy - Viruses, 2024 - mdpi.com
Since the emergence of the SARS-CoV-2 virus in 2019, nearly 700 million COVID-19 cases
and 7 million deaths have been reported globally. Despite most individuals recovering …

Mechanisms by Which SARS-CoV-2 Invades and Damages the Central Nervous System: Apart from the Immune Response and Inflammatory Storm, What Else Do We …

Z Sun, C Shi, L Jin - Viruses, 2024 - mdpi.com
Initially reported as pneumonia of unknown origin, COVID-19 is increasingly being
recognized for its impact on the nervous system, despite nervous system invasions being …