Oligodendrocyte precursor cells (OPCs) account for 5% of the resident parenchymal central
nervous system glial cells. OPCs are not only a back-up for the loss of oligodendrocytes that …

An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Currently, it is possible to study the pathogenesis of Tourette's syndrome (TS) in more detail,
due to more advanced methods of neuroimaging. However, medical and surgical treatment …

Neurotransmitter transporters limit spillover between synapses and maintain the
extracellular neurotransmitter concentration at low yet physiologically meaningful levels …

The striatum is a key hub in the basal ganglia for processing neural information from the
sensory, motor, and limbic cortices. The massive and diverse cortical inputs entering the …

Effective pharmacological and psychotherapeutic treatments are well established for
obsessive-compulsive disorder (OCD). Serotonin reuptake inhibitors (SRIs) are first-line …

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder characterized by
intrusive obsessive thoughts and compulsive behaviors. Multiple studies have shown the …

The solute carrier (SLC) family, with more than 400 membrane-bound proteins, facilitates the
transport of a wide array of substrates such as nutrients, ions, metabolites, and drugs across …

Obsessive-compulsive disorder (OCD) is a disabling condition that often begins in
childhood. Genetic studies in OCD have pointed to SLC1A1, which encodes the neuronal …

Obsessive-compulsive disorder (OCD) is a chronic, severe psychiatric disorder that has
been ranked by the World Health Organization as one of the leading causes of illness …