Advances in catalytic enantioselective fluorination, mono-, di-, and trifluoromethylation, and trifluoromethylthiolation reactions

X Yang, T Wu, RJ Phipps, FD Toste - Chemical reviews, 2015 - ACS Publications
1. INTRODUCTION Despite being largely absent from natural products and biological
processes, fluorine plays a conspicuous and increasingly important role within …

Monofluorination of organic compounds: 10 years of innovation

PA Champagne, J Desroches, JD Hamel… - Chemical …, 2015 - ACS Publications
Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Introduction of fluorine and fluorine‐containing functional groups

T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …

Einführung von Fluor und fluorhaltigen funktionellen Gruppen

T Liang, CN Neumann, T Ritter - Angewandte Chemie, 2013 - Wiley Online Library
Die wichtigsten konzeptionellen Fortschritt auf dem Gebiet der Fluorierungen der letzten
zehn Jahre wurden durch die Organo‐und Übergangsmetallkatalyse ermöglicht. Die …

Recent advances in catalytic enantioselective fluorination reactions

S Lectard, Y Hamashima… - Advanced Synthesis & …, 2010 - Wiley Online Library
Since the incorporation of fluorine into biologically active compounds often enhances the
properties of the parent compounds, there is a considerable demand for efficient …

Fluorine & chirality: how to create a nonracemic stereogenic carbon–fluorine centre?

D Cahard, X Xu, S Couve-Bonnaire… - Chemical Society …, 2010 - pubs.rsc.org
Enantiopure organofluorine compounds are at the forefront of innovation in the field of
fluorine chemistry. The significant progress in modern fluoroorganic chemistry parallels the …

Asymmetric Aldol Reaction of Acetaldehyde and Isatin Derivatives for the Total Syntheses of ent-Convolutamydine E and CPC-1 and a Half Fragment of Madindoline …

T Itoh, H Ishikawa, Y Hayashi - Organic letters, 2009 - ACS Publications
The asymmetric aldol reaction of isatin derivatives and acetaldehyde has been developed
using 4-hydroxydiarylprolinol as a catalyst, affording the aldol products with high …

Asymmetric synthesis with silicon‐based bulky amino organocatalysts

LW Xu, L Li, ZH Shi - Advanced Synthesis & Catalysis, 2010 - Wiley Online Library
Recent years have witnessed an explosive growth in the field of amino organocatalysis,
especially in asymmetric enamine and iminium catalysis. Except for the obvious interaction …

Palladium-catalyzed asymmetric synthesis of allylic fluorides

MH Katcher, AG Doyle - Journal of the American Chemical …, 2010 - ACS Publications
The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has
been accomplished using a Pd (0) catalyst and Trost bisphosphine ligand. The reactions …

Enantioselective organocatalytic synthesis of fluorinated molecules

G Valero, X Companyó, R Rios - Chemistry–A European …, 2011 - Wiley Online Library
The enantioselective synthesis of fluorinated molecules has drawn much attention within the
chemical community due to its unique stereoelectronic properties. The main aim of this …