The taxanes are an important new class of anticancer agents that exert their cytotoxic effects
through a unique mechanism. Paclitaxel (Taxol), the first taxane in clinical trials, is active …

▪ Abstract The taxane class of antimicrotubule anticancer agents is perhaps the most
important addition to the chemotherapeutic armamentarium against cancer over the past …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

The last decade witnessed the introduction of exciting new chemotherapeutic agents.
Among these, paclitaxel emerged as one of the most powerful compounds. Paclitaxel …

Paclitaxel | Drugs Skip to main content SpringerLink Account Menu Find a journal Publish with
us Track your research Search Cart 1.Home 2.Drugs 3.Article Paclitaxel A Review of its …

PURPOSE To define the maximum-tolerated dose (MTD) and better tolerated sequence of
paclitaxel by 3-hour infusion plus bolus doxorubicin (DOX) and to evaluate antitumor …

Purpose ABI-007 is a novel nanoparticle, albumin-bound paclitaxel that is free of solvents.
This multicenter phase II study was designed to evaluate the efficacy and safety of ABI-007 …

Background. Paclitaxel-induced peripheral neuropathy (PN) may be severeand dose-
limiting at initial doses≥ 275 mg/M 2, but itsneurotoxicity at doses≤ 250 mg/M 2 has been …

Background Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity
of several commonly used chemotherapy drugs including taxanes, vinca alkaloids, and …

BACKGROUND Systemic anticancer therapies can produce acute and chronic organ
damage, but the eye is usually considered a protected site. Nonetheless, the oculovisual …