Ischaemia‐reperfusion injury is a complex phenomenon often encountered in surgical
practice. The consequences of such injury are local and remote tissue destruction, and …

A. Cyclic nucleotides 112 B. Phosphoinoside hydrolysis ii3 C. Protein kinases 113 D.
Calcium channels 113 E. Potassium channels ii4 VII. Pulmonary vasodilators as therapy 114 …

Objective To evaluate blood pressure and humoral vasoconstrictor responses to recurrent
episodes of obstructive sleep apnea and the effects of therapy by means of continuous …

Background Endothelin is a powerful vasoconstrictor peptide derived from the endothelium.
We evaluated the contribution of endothelin to blood-pressure regulation in patients with …

Endothelin-1 is an endothelium-derived vasoconstrictor peptide, possibly involved in the
pathophysiology of cardiovascular disease. We examined the contribution of endogenously …

The molecular basis for the β-cell dysfunction that characterizes non-insulin-dependent
diabetes mellitus (NIDDM) is unknown. The Zucker diabetic fatty (ZDF) male rat is a rodent …

Background Although local inhibition of the generation or actions of endothelin-1 has been
shown to cause forearm vasodilatation, the systemic effects of endothelin receptor blockade …

In addition to their vasoactive action, endothelins are potent peptides in the regulation of
both cell proliferation and the turnover of extracellular matrix. Using immunohistochemical …

Large artery stiffness is a frequent condition that arises with ageing, and is accelerated by
the presence of co‐morbidities like hypertension, obesity and diabetes. Although …

The endothelins are a family of 21–amino acid peptides that are powerful vasoconstrictors.
They may also induce vascular hypertrophy. These peptides may participate through these …