Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Large herbivores play unique ecological roles and are disproportionately imperiled by
human activity. As many wild populations dwindle towards extinction, and as interest grows …

Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Volatile organic compounds play essential roles in plant environment interactions as well as
determining the fragrance of plants. Although gas chromatography-mass spectrometry …

Although much is known about plant traits that function in nonhost resistance against
pathogens, little is known about nonhost resistance against herbivores, despite its …

Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …

Public repositories of metabolomics mass spectra encompass more than 1 billion entries.
With open search, dot product or entropy similarity, comparisons of a single tandem mass …

Specialized metabolite (SM) diversification is a core process to plants' adaptation to diverse
ecological niches. Here, we implemented a computational mass spectrometry–based …

Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may
therefore substitute blood in drug analysis. However, current ISF extraction techniques …