The article discusses the guidelines of the United Kingdom Haemophilia Centre Doctors'
Organization (UKHCDO) related to the diagnosis and management of patients with rare …

Background: The European Network of Rare Bleeding Disorders (EN‐RBD) was established
to bridge the gap between knowledge and practise in the care of patients with RBDs …

Combined deficiency of factor V (FV) and FVIII (F5F8D) is an autosomal recessive bleeding
disorder characterized by simultaneous decreases of both coagulation factors. This review …

ABSTRACT Background: Rare bleeding disorders (RBDs) are heterogeneous disorders,
mostly inherited in an autosomal recessive pattern. Iran is a Mideast country with a high rate …

Mutations in LMAN1 (ERGIC-53) or MCFD2 cause combined deficiency of factor V and
factor VIII (F5F8D). LMAN1 and MCFD2 form a protein complex that functions as a cargo …

Rare bleeding disorders (RBDs) are a heterogeneous group of coagulation factor
deficiencies that include fibrinogen, prothrombin, α 2-antiplasmin, plasminogen activator …

Introduction The rare coagulation disorders may present significant difficulties in diagnosis
and management. In addition, considerable inter‐individual variation in bleeding phenotype …

Inherited deficiencies of plasma proteins involved in blood coagulation generally lead to
lifelong bleeding disorders. The severity of these disorders is generally inversely …

Combined deficiency of factor V (FV) and factor VIII (FVIII)(F5F8D) is a genetic disorder
characterized by mild‐to‐moderate bleeding and coordinate reduction in plasma FV and …

Combined factor V (FV) and FVIII deficiency (F5F8D) is a rare autosomal-recessive bleeding
disorder caused by mutations in lectin mannose binding-1 (LMAN1) and multiple …