Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for developing individualized …
molecular underpinnings of this variability is of great relevance for developing individualized …
[HTML][HTML] Stress and the HPA axis: role of glucocorticoids in alcohol dependence
MAC Stephens, G Wand - Alcohol research: current reviews, 2012 - ncbi.nlm.nih.gov
Stress has long been suggested to be an important correlate of uncontrolled drinking and
relapse. An important hormonal response system to stress—the hypothalamic–pituitary …
relapse. An important hormonal response system to stress—the hypothalamic–pituitary …
The concept of stress in fish
CB Schreck, L Tort - Fish physiology, 2016 - Elsevier
1. Introduction 1.1. What Is Stress? 1.2. Dynamics of the Stress Response and Effects on
Performance 1.3. Contemporary View of the GAS: Eustress versus Distress 1.4. Sensory …
Performance 1.3. Contemporary View of the GAS: Eustress versus Distress 1.4. Sensory …
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Although the fact that genetic predisposition and environmental exposures interact to shape
development and function of the human brain and, ultimately, the risk of psychiatric …
development and function of the human brain and, ultimately, the risk of psychiatric …
Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk
AS Zannas, M Jia, K Hafner… - Proceedings of the …, 2019 - National Acad Sciences
Aging and psychosocial stress are associated with increased inflammation and disease risk,
but the underlying molecular mechanisms are unclear. Because both aging and stress are …
but the underlying molecular mechanisms are unclear. Because both aging and stress are …
The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to …
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Early life stress, such as childhood abuse, neglect and loss, is a well established major risk
factor for developing depressive disorders later in life. We here summarize and discuss …
factor for developing depressive disorders later in life. We here summarize and discuss …
Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation
N Provençal, J Arloth, A Cattaneo… - Proceedings of the …, 2020 - National Acad Sciences
Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This
may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known …
may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known …
Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
Background Chronic psychological stress is associated with accelerated aging and
increased risk for aging-related diseases, but the underlying molecular mechanisms are …
increased risk for aging-related diseases, but the underlying molecular mechanisms are …
Epigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD
R Yehuda, NP Daskalakis, F Desarnaud… - Frontiers in …, 2013 - frontiersin.org
Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known
whether these measures associate with, or predict, clinical state. These questions were …
whether these measures associate with, or predict, clinical state. These questions were …