The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

X Fang, H Ardehali, J Min, F Wang - Nature Reviews Cardiology, 2023 - nature.com
The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Y Yu, Y Yan, F Niu, Y Wang, X Chen, G Su, Y Liu… - Cell death …, 2021 - nature.com
Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …

Ferroptosis: opportunities and challenges in myocardial ischemia‐reperfusion injury

W Zhao, Y Zhou, T Xu, Q Wu - Oxidative Medicine and Cellular …, 2021 - Wiley Online Library
Ferroptosis is a newly discovered form of regulated cell death dependent on iron and
reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione …

Human umbilical cord blood–derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice

Y Song, B Wang, X Zhu, J Hu, J Sun, J Xuan… - Cell Biology and …, 2021 - Springer
The exosome of MSCs derived from human umbilical cord blood (HUCB-MSC) has been
reported to have cardioprotective effects on mouse models of acute myocardial infarction …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis

JW Kim, JY Lee, M Oh, EW Lee - Experimental & Molecular Medicine, 2023 - nature.com
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid
peroxidation. This process contributes to cellular and tissue damage in various human …

[HTML][HTML] Ferroptosis and its role in cardiomyopathy

D Li, W Pi, Z Sun, X Liu, J Jiang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Heart disease is the leading cause of death worldwide. Cardiomyopathy is a disease
characterized by the heart muscle damage, resulting heart in a structurally and functionally …

Ferroptosis and cardiovascular disease: role of free radical-induced lipid peroxidation

X Chen, X Li, X Xu, L Li, N Liang, L Zhang… - Free radical …, 2021 - Taylor & Francis
Cardiovascular disease (CVD), including heart attack, stroke, heart failure, arrhythmia, and
other congenital heart diseases remain the leading cause of morbidity and mortality …

Adipose tissue macrophage-derived exosomes induce ferroptosis via glutathione synthesis inhibition by targeting SLC7A11 in obesity-induced cardiac injury

X Zhao, L Si, J Bian, C Pan, W Guo, P Qin… - Free Radical Biology …, 2022 - Elsevier
Ferroptosis is an iron-dependent programmed cell death characterized by the accumulation
of reactive oxygen species (ROS). Long-term high fat diet (HFD) was found to be associated …

Ferroptosis MRI for early detection of anticancer drug–induced acute cardiac/kidney injuries

F Zeng, S Nijiati, Y Liu, Q Yang, X Liu, Q Zhang… - Science …, 2023 - science.org
Ferroptosis has been realized in anticancer drug–induced acute cardiac/kidney injuries
(ACI/AKI); however, molecular imaging approach to detect ferroptosis in ACI/AKI is a …