Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and
leukotrienes, impact the immune system, usually as proinflammatory factors. Other …

None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

Objective Narcolepsy is caused by loss of the hypothalamic neurons producing the
orexin/hypocretin neuropeptides. One key target of the orexin system is the histaminergic …

The growing importance of nanomaterials toward the detection of neurotransmitter
molecules has been chronicled in this review. Neurotransmitters (NTs) are chemicals that …

Histamine and hypocretin neurons are localized to the hypothalamus, a brain area critical to
autonomic function and sleep. Narcolepsy type 1, also known as narcolepsy with cataplexy …

Histamine is an amine acting as a major peripheral inflammatory mediator. In the brain,
histamine was initially viewed as a neurotransmitter, but new evidences support its …

Histamine does not only modulate the immune response and inflammation, but also acts as
a neurotransmitter in the mammalian brain. The histaminergic system plays a significant role …

Increased sleep need following traumatic brain injury, referred to in this study as post‐
traumatic pleiosomnia, is common, but so far its clinical impact and therapeutic implications …

Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate
the immune system, but is also acting as a neurotransmitter. Histaminergic neurons project …

Histamine is a major peripheral inflammatory mediator and a neurotransmitter in the central
nervous system. We have reported that histamine induces microglia activation and releases …