Cardiac cachexia: a systematic overview

S von Haehling, M Lainscak, J Springer… - Pharmacology & …, 2009 - Elsevier
Cardiac cachexia as a terminal stage of chronic heart failure carries a poor prognosis. The
definition of this clinical syndrome has been a matter of debate in recent years. This review …

Inflammatory biomarkers in heart failure revisited: much more than innocent bystanders

S von Haehling, JC Schefold… - Heart failure …, 2009 - heartfailure.theclinics.com
Chronic heart failure (CHF) is underrecognized and remains underestimated as a public
health challenge. This condition is associated with a poor prognosis and has been …

[HTML][HTML] Curcumin modulates macrophage polarization through the inhibition of the toll-like receptor 4 expression and its signaling pathways

Y Zhou, T Zhang, X Wang, X Wei, Y Chen… - Cellular Physiology and …, 2015 - karger.com
Background: Curcumin, the active ingredient in curcuma rhizomes, has a wide range of
therapeutic effects. However, its atheroprotective activity in human acute monocytic …

The gut and intestinal bacteria in chronic heart failure

A Sandek, SD Anker, S Haehling - Current drug metabolism, 2009 - ingentaconnect.com
Chronic heart failure (CHF) is now recognized as a multisystem disorder with increased
sympathetic tone, hormonal derangements, an anabolic/catabolic imbalance, endothelial …

Use of Toll-Like Receptor agonist for treating cancer

A Gleiberman, L Burdelya, A Gudkov - US Patent 9,376,473, 2016 - Google Patents
PIRWNASAJNPKHT-SHZATDIYSA-N PAMP Chemical compound C ([C@@ H](C (= O) N
[C@@ H](CCCNC (N)= N) C (= O) N [C@@ H](CCCCN) C (= O) N [C@@ H](CCCCN) C …

Enhanced platelet toll-like receptor 2 and 4 expression in acute coronary syndrome and stable angina pectoris

KM Gurses, D Kocyigit, MU Yalcin, H Canpinar… - The American journal of …, 2015 - Elsevier
Evidence is accumulating that toll-like receptors (TLR) are involved in the initiation and
progression of cardiovascular disease. Enhanced expression of these receptors on …

Cell-penetrating TIR BB loop decoy peptides: a novel class of TLR signaling inhibitors and a tool to study topology of TIR–TIR interactions

VY Toshchakov, SN Vogel - Expert opinion on biological therapy, 2007 - Taylor & Francis
Toll-like receptors (TLR), a family of closely related type I, transmembrane, signal
transducing proteins, sense invading pathogens early in the immune response to infection …

Prosarcopenic effects of statins may limit their effectiveness in patients with heart failure

A Bielecka-Dabrowa, J Fabis, DP Mikhailidis… - Trends in …, 2018 - cell.com
Some studies using small doses of statins revealed significant benefits for patients with
chronic heart failure (HF). However, the results of large randomized studies did not confirm …

Toll like receptors in liver ischemia reperfusion injury: a novel target for therapeutic modulation?

A Katsargyris, C Klonaris, A Alexandrou… - Expert opinion on …, 2009 - Taylor & Francis
Background: There is increasing evidence that Toll-like receptors (TLRs) sense host tissue
damage by engaging with endogenous ligands. TLRs are considered to be involved in …

Methods for treating reperfusion injuries using flagellin

A Gudkov, R Fairchild - US Patent 8,618,059, 2013 - Google Patents
US8618059B2 - Methods for treating reperfusion injuries using flagellin - Google Patents
US8618059B2 - Methods for treating reperfusion injuries using flagellin - Google Patents …