Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Covering: 2012 to 2021 Cyclopropane attracts wide interests in the fields of synthetic and
pharmaceutical chemistry, and chemical biology because of its unique structural and …

Authored by leading experts in the enzymology of natural product biosynthesis, this textbook
provides a thorough description of the types of natural products, the biosynthetic pathways …

Transition metal‐catalyzed site‐and stereoselective C− H activation of strained (hetero)
cycloalkanes remains a formidable challenge. We herein report a carbamate‐directed …

Bacterial natural products display astounding structural diversity, which, in turn, endows
them with a remarkable range of biological activities that are of significant value to modern …

Bacteria of the Burkholderia pseudomallei (BP) group pose a global health threat, causing
the infectious diseases melioidosis, a common cause of pneumonia and sepsis, and …

Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) are among the most
complex enzymes, which are responsible for generating a wide range of natural products …

Amphotericin-like glycosylated polyene macrolides (GPMs) are a clinically and industrially
important family of natural products, but the mechanisms by which they exert their …

Lanthanides (Ln) are a new group of life metals, and many questions remain regarding how
they are acquired and used in biology. Methylotrophic bacteria can acquire, transport …