COVID-19 and cardiac injury: clinical manifestations, biomarkers, mechanisms, diagnosis, treatment, and follow up

A Tajbakhsh, SM Gheibi Hayat… - Expert review of anti …, 2021 - Taylor & Francis
ABSTRACT Introduction Coronavirus disease 2019 (COVID-19) has the characteristics of
high transmission, diverse clinical manifestations, and a long incubation period. In addition …

[HTML][HTML] Natural history of COVID-19 and current knowledge on treatment therapeutic options

WG Dos Santos - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Despite intense research there is currently no effective vaccine available against the new
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in the later 2019 …

[HTML][HTML] Multi-domain clinical natural language processing with MedCAT: the medical concept annotation toolkit

Z Kraljevic, T Searle, A Shek, L Roguski, K Noor… - Artificial intelligence in …, 2021 - Elsevier
Electronic health records (EHR) contain large volumes of unstructured text, requiring the
application of information extraction (IE) technologies to enable clinical analysis. We present …

Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study

E Carr, R Bendayan, D Bean, M Stammers, W Wang… - BMC medicine, 2021 - Springer
Abstract Background The National Early Warning Score (NEWS2) is currently recommended
in the UK for the risk stratification of COVID-19 patients, but little is known about its ability to …

The cytokine storm of COVID-19: a spotlight on prevention and protection

L Pearce, SM Davidson, DM Yellon - Expert Opinion on …, 2020 - Taylor & Francis
Introduction The cytokine release syndrome (CRS) of COVID-19 is associated with the
development of critical illness requiring multi-organ support. Further research is required to …

The prognostic value of comorbidity for the severity of COVID-19: A systematic review and meta-analysis study

M Fathi, K Vakili, F Sayehmiri, A Mohamadkhani… - PloS one, 2021 - journals.plos.org
Background and objectives With the increase in the number of COVID-19 infections, the
global health apparatus is facing insufficient resources. The main objective of the current …

Estimation of renin-angiotensin-aldosterone-system (RAAS)-inhibitor effect on COVID-19 outcome: a meta-analysis

CJ Pirola, S Sookoian - Journal of Infection, 2020 - Elsevier
Background and rationale Some studies of hospitalized patients suggested that the risk of
death and/or severe illness due to COVID-19 is not associated with the use of angiotensin …

Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions

IL Kruglikov, M Shah, PE Scherer - Elife, 2020 - elifesciences.org
Obesity and diabetes are established comorbidities for COVID-19. Adipose tissue
demonstrates high expression of ACE2 which SARS-CoV-2 exploits to enter host cells. This …

Association of angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers with the risk of hospitalization and death in hypertensive patients with …

R Khera, C Clark, Y Lu, Y Guo, S Ren… - Journal of the …, 2021 - Am Heart Assoc
Background Despite its clinical significance, the risk of severe infection requiring
hospitalization among outpatients with severe acute respiratory syndrome coronavirus 2 …

ACE2 (Angiotensin-Converting Enzyme 2) in cardiopulmonary diseases: ramifications for the control of SARS-CoV-2

RK Sharma, BR Stevens, AG Obukhov, MB Grant… - …, 2020 - Am Heart Assoc
Discovery of ACE2 (angiotensin-converting enzyme 2) revealed that the renin-angiotensin
system has 2 counterbalancing arms. ACE2 is a major player in the protective arm, highly …