Sildenafil, approved two decades ago, is the inhibitor of phosphodiesterase 5 (PDE5). First
of all, it was designated for angina pectoris, but soon it showed a wonderful efficacy in …

Ischaemia/reperfusion injury is an important cause of liver damage during surgical
procedures such as hepatic resection and liver transplantation, and represents the main …

Abstract Background and aim The Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-
κB)/NLRP3 inflammasome signaling pathway is essential in the pathogenesis of hepatic …

The Toll‐like receptor‐4 (TLR4)/nuclear factor kappa B (NF‐κB) signaling pathway is vital in
the pathogenesis of hepatic ischemia/reperfusion (HIR) injury. Dipeptidyl peptidase‐4 …

Hepatic ischemia-reperfusion (HIR) injury is a common pathophysiological process in many
clinical settings. This study was designed to compare the protective role of octreotide …

Alzheimer disease (AD) is a chronic neurodegenerative disease with multi-pathways
pathogenesis. Sildenafil is a selective phosphodiesterase-5 inhibitor with a potential benefit …

Sildenafil is the first phosphodiesterase-5 inhibitor used for the treatment of erectile
dysfunction. However, recent studies have been suggesting an antitumor effect of sildenafil …

Materials and Methods: Forty eight rats were randomized into the following eight groups:(1)
Control-sham group: rats subjected to the surgical procedure, except for liver I/R;(2) DMSO …

Ischemia reperfusion (IR) injury occurs in many clinical situations such as organ
transplantation and hepatectomies resulting in oxidative stress and immune activation …

Ischemia and reperfusion (I/R)–induced injury has been described as one of the main
factors that contribute to the observed morbidity and mortality in a variety of clinical entities …