Epithelial barriers in allergy and asthma

PW Hellings, B Steelant - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
The respiratory epithelium provides a physical, functional, and immunologic barrier to
protect the host from the potential harming effects of inhaled environmental particles and to …

Epithelial cell dysfunction, a major driver of asthma development

IH Heijink, VNS Kuchibhotla, MP Roffel, T Maes… - Allergy, 2020 - Wiley Online Library
Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases

W Rokicki, M Rokicki, J Wojtacha… - … i Torakochirurgia Polska …, 2016 - termedia.pl
The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory
diseases Page 1 Kardiochirurgia i Torakochirurgia Polska 2016; 13 (1) 26 Address for …

Characterization of a lung epithelium specific E-cadherin knock-out model: Implications for obstructive lung pathology

S Post, IH Heijink, L Hesse, HK Koo, F Shaheen… - Scientific reports, 2018 - nature.com
The airway epithelium regulates responses to aeroallergens, acting as a physical and
immunological barrier. In asthma, epithelial barrier function and the expression of adherens …

E‐cadherin's role in development, tissue homeostasis and disease: Insights from mouse models: Tissue‐specific inactivation of the adhesion protein E‐cadherin in …

MR Schneider, FT Kolligs - Bioessays, 2015 - Wiley Online Library
Recent studies uncovered critical roles of the adhesion protein E‐cadherin in health and
disease. Global inactivation of Cdh1, the gene encoding E‐cadherin in mice, results in early …

[HTML][HTML] Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion

M Di Domenico, A Giordano - Oncotarget, 2017 - ncbi.nlm.nih.gov
Giulio Bizzozero classified the tissues concerning their capacity to self-renew during the
adult life in labile, stable and permanent tissues. In 1940 Viktor Hamburger and Rita Levi …

Fungal Aeroallergens—The Impact of Climate Change

M Sztandera-Tymoczek, A Szuster-Ciesielska - Journal of Fungi, 2023 - mdpi.com
The incidence of allergic diseases worldwide is rapidly increasing, making allergies a
modern pandemic. This article intends to review published reports addressing the role of …

[HTML][HTML] Airway epithelium IgE-FcεRI cross-link induces epithelial barrier disruption in severe T2-high asthma

CM Weng, MJ Lee, W Chao, YR Lin, CJ Chou… - Mucosal …, 2023 - Elsevier
Although high-affinity immunoglobulin (Ig) E receptor (FcεRI) expression is upregulated in
type 2 (T2)-high asthmatic airway epithelium, its functional role in airway epithelial …

Epithelial cell plasticity defines heterogeneity in lung cancer

P Sarode, S Mansouri, A Karger, MB Schaefer… - Cellular …, 2020 - Elsevier
Lung cancer is the leading cause of cancer death for both men and women and accounts for
almost 18.4% of all deaths due to cancer worldwide, with the global incidence increasing by …

Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma

X Dong, M Ding, J Zhang, I Ogülür, Y Pat… - Chinese Medical …, 2022 - mednexus.org
Type 2 inflammation is a complex immune response and primary mechanism for several
common allergic diseases including allergic rhinitis, allergic asthma, atopic dermatitis, and …