An insight into reprogramming barriers to iPSC generation
Abstract Derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming somatic
cells to a pluripotent state has revolutionized stem cell research. Ensuing this, various …
cells to a pluripotent state has revolutionized stem cell research. Ensuing this, various …
Biological importance of OCT transcription factors in reprogramming and development
KP Kim, DW Han, J Kim, HR Schöler - Experimental & molecular …, 2021 - nature.com
Abstract Ectopic expression of Oct4, Sox2, Klf4 and c-Myc can reprogram somatic cells into
induced pluripotent stem cells (iPSCs). Attempts to identify genes or chemicals that can …
induced pluripotent stem cells (iPSCs). Attempts to identify genes or chemicals that can …
[HTML][HTML] A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming
Somatic cells can be reprogrammed into pluripotent stem cells (PSCs) by using pure
chemicals, providing a different paradigm to study somatic reprogramming. However, the …
chemicals, providing a different paradigm to study somatic reprogramming. However, the …
[HTML][HTML] Excluding Oct4 from Yamanaka cocktail unleashes the developmental potential of iPSCs
S Velychko, K Adachi, KP Kim, Y Hou, CM MacCarthy… - Cell Stem Cell, 2019 - cell.com
Oct4 is widely considered the most important among the four Yamanaka reprogramming
factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for …
factors. Here, we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for …
Permissive epigenomes endow reprogramming competence to transcriptional regulators
KP Kim, J Choi, J Yoon, JM Bruder, B Shin… - Nature Chemical …, 2021 - nature.com
Identifying molecular and cellular processes that regulate reprogramming competence of
transcription factors broadens our understanding of reprogramming mechanisms. In the …
transcription factors broadens our understanding of reprogramming mechanisms. In the …
[HTML][HTML] Paternal preconception phthalate exposure alters sperm methylome and embryonic programming
Preconception environmental conditions have been demonstrated to shape sperm
epigenetics and subsequently offspring health and development. Our previous findings in …
epigenetics and subsequently offspring health and development. Our previous findings in …
H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation
Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers.
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …
Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds
Recently, we reported a chemical approach to generate pluripotent stem cells from mouse
fibroblasts. However, whether chemically induced pluripotent stem cells (CiPSCs) can be …
fibroblasts. However, whether chemically induced pluripotent stem cells (CiPSCs) can be …
Reprogramming competence of OCT factors is determined by transactivation domains
KP Kim, Y Wu, J Yoon, K Adachi, G Wu, S Velychko… - Science …, 2020 - science.org
OCT4 (also known as POU5F1) plays an essential role in reprogramming. It is the only
member of the POU (Pit-Oct-Unc) family of transcription factors that can induce pluripotency …
member of the POU (Pit-Oct-Unc) family of transcription factors that can induce pluripotency …
[HTML][HTML] Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks
TL Davis, I Rebay - Developmental biology, 2017 - Elsevier
Among the mechanisms that steer cells to their correct fate during development, master
regulatory networks are unique in their sufficiency to trigger a developmental program …
regulatory networks are unique in their sufficiency to trigger a developmental program …