Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)

F Dayyani, CJ Etzel, M Liu, CH Ho, SM Lippman… - Head & neck …, 2010 - Springer
Background HPV is important in a subset of HNSCC. Our meta-analysis determined the
clinical characteristics of HPV-related HNSCC. Method Pubmed search terms" HPV" and" …

The clinical impact of HPV tumor status upon head and neck squamous cell carcinomas

E Benson, R Li, D Eisele, C Fakhry - Oral oncology, 2014 - Elsevier
Human papillomavirus (HPV) is etiologically responsible for a distinct subset of head and
neck squamous cell cancers (HNSCCs). HPV-positive HNSCCs (HPV-HNSCCs) most …

p16 expression as a surrogate marker for HPV‐related oropharyngeal carcinoma: a guide for interpretative relevance and consistency

AK El‐Naggar, WH Westra - Head & neck, 2012 - Wiley Online Library
Recent studies of oropharyngeal carcinoma have reported remarkable correlation between
integrated human papillomavirus (HPV) viral detection and p16 protein overexpression in …

Meta analysis: HPV and p16 pattern determines survival in patients with HNSCC and identifies potential new biologic subtype

AE Albers, X Qian, AM Kaufmann, A Coordes - Scientific reports, 2017 - nature.com
Consistent discrepancies in the p16/HPV-positivity have been observed in head and neck
squamous cell carcinoma (HNSCC). It is therefore questionable, if all HPV+ and/or p16+ …

A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer

NF Schlecht, M Brandwein-Gensler, GJ Nuovo, M Li… - Modern …, 2011 - nature.com
Detection of human papillomavirus (HPV) in head and neck cancer has therapeutic
implications. In situ hybridization and immunohistochemistry for p16 are used by surgical …

Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement

D Holzinger, M Schmitt, G Dyckhoff, A Benner… - Cancer research, 2012 - AACR
Oropharyngeal squamous cell carcinomas (OPSCC) that are associated with human
papilloma virus (HPV) infection carry a more favorable prognosis than those that are HPV …

Transoral laser microsurgery (TLM)±adjuvant therapy for advanced stage oropharyngeal cancer: outcomes and prognostic factors

JT Rich, S Milov, JS Lewis Jr, WL Thorstad… - The …, 2009 - Wiley Online Library
Abstract Objectives/Hypothesis: Document survival, prognostic variables, and functional
outcomes of patients with AJCC stage III or IV oropharyngeal cancer, treated with transoral …

Is p16-positive oropharyngeal squamous cell carcinoma associated with favorable prognosis? A systematic review and meta-analysis

PP Sedghizadeh, WD Billington, D Paxton, R Ebeed… - Oral oncology, 2016 - Elsevier
The purpose of this systematic review and meta-analysis was to compare the prognosis of
patients with p16 expressing oropharyngeal squamous cell cancers to patients with p16 non …

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

SG Craig, LA Anderson, AG Schache, M Moran… - British Journal of …, 2019 - nature.com
Background TNM8 staging for oropharyngeal squamous cell carcinomas (OPSCC)
surrogates p16 immunohistochemistry for HPV testing. Patients with p16+ OPSCC may lack …

Biological evidence for a causal role of HPV16 in a small fraction of laryngeal squamous cell carcinoma

G Halec, D Holzinger, M Schmitt… - British journal of …, 2013 - nature.com
Background: Human papillomavirus (HPV) is a causal factor in virtually all cervical and a
subset of oropharyngeal squamous cell carcinoma (OP-SCC), whereas its role in laryngeal …