Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Oxidative stress is increasingly recognized as a central event contributing to the
degeneration of dopaminergic neurons in the pathogenesis of Parkinson's disease (PD) …

Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

Mitochondria are the key source of ATP that fuels cellular functions, and they are also central
in cellular signaling, cell division and apoptosis. Dysfunction of mitochondria has been …

Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

Ischemic heart disease (IHD) remains the leading cause of death and disability worldwide.
For patients presenting with an acute myocardial infarction, the most effective treatment for …

The term mitochondrial permeability transition (MPT) is commonly used to indicate an abrupt
increase in the permeability of the inner mitochondrial membrane to low molecular weight …

Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, has been
reported to show essential roles in molecular pathophysiology of many diseases …

Ischemia/reperfusion, which is characterized by deficient oxygen supply and subsequent
restoration of blood flow, can cause irreversible damages to tissue. Mechanisms contributing …

Several insults cause the inner mitochondrial membrane to abruptly lose osmotic
homeostasis, hence initiating a regulated variant of cell death known as 'mitochondrial …