Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues
and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome …

Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its
effect on the skin is poorly understood. Here, we show that CR mice display fur coat …

Abstract Background/Purpose We previously demonstrated that irradiation with red light
accelerates recovery of the epidermal water‐impermeable barrier, whereas blue light delays …

Epidermal energy metabolism is relevant to skin physiology, ageing and photodamage.
While selected hormones stimulate epidermal keratinocyte mitochondrial activity, its …

Assessing the metabolic activity of a tissue, whether normal, damaged, aged, or pathologic,
is useful for diagnosis and evaluating the effects of drugs. This report describes a handheld …

In the last few years, mitochondria have exited from the shadows to take centre stage in the
aetiology of several skin disorders. Thus, the role of mitochondrial energy metabolism in …

The skin, the most external organ of the body, is constituted by a variety of cells, including
keratinocytes, fibroblasts, melanocytes, and a wide diversity of immune cells. After exposure …