Regulator of G-protein signalling (RGS) proteins form a superfamily of at least 25 proteins,
which are highly diverse in structure, expression patterns, and function. They share a 120 …

The endothelium, lining the inner surface of blood vessels, can be considered as the main
local regulator of vascular wall homeostasis. It secretes various factors in response to …

Emerging evidence indicates that reactive oxygen species are important regulators of
vascular function. Although NAD (P) H oxidases have been implicated as major sources of …

Angiotensin II is a multifunctional hormone that affects both contraction and growth of
vascular smooth muscle cells through a complex series of intracellular signaling events …

Activation of phospholipase C (PLC) is one of the earliest events in angiotensin II (Ang II)
type 1 (AT 1) receptor (R)-mediated signal transduction in vascular smooth muscle cells …

In cultured vascular smooth muscle cells (VSMCs), Janus kinases (JAKs) and signal
transducers and activators of transcription (STATs) are expressed constitutively and play a …

The roles of adventitial vasa vasorum have been highlighted in vascular wall homeostasis.
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor in physiological and …

Inappropriate activation of the type 1A angiotensin (AT 1A) receptor contributes to the
pathogenesis of hypertension and its associated complications. To define the role for actions …

A role of interferon-γ is suggested in early development of atherosclerosis. However, the role
of interferon-γ in progression and destabilization of advanced atherosclerotic plaques …

In cultured vascular smooth muscle cells (VSMCs), activation of phospholipase D (PLD) by
angiotensin II (Ang II) represents a major source of sustained generation of second …