One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

At the post-transcriptional level, expression of protein-coding genes is controlled by a series
of RNA regulatory events including nuclear processing of primary transcripts, transport of …

Spliceosomal snRNPs are multicomponent particles that undergo a complex maturation
pathway. Human Sm-class snRNAs are generated as 3′-end extended precursors, which …

Spliceosomal small nuclear ribonucleoproteins (snRNPs) are essential components of the
nuclear pre-mRNA processing machinery. A hallmark of these particles is a ring-shaped …

Protein arginine methylation plays a critical role in differential gene expression through
modulating protein-protein and protein-DNA/RNA interactions. Although numerous proteins …

Proper orchestration of the thousands of biochemical processes that are essential to the life
of every cell requires highly organized cellular compartmentalization of dedicated …

The mechanisms by which poikilothermic organisms ensure that biological processes are
robust to temperature changes are largely unknown. Temperature compensation, the ability …

Virtually, all eukaryotic mRNAs are synthesized as precursor molecules that need to be
extensively processed in order to serve as a blueprint for proteins. The three most prevalent …

Trypanosomatids are early-diverged, protistan parasites of which Trypanosoma brucei,
Trypanosoma cruzi, and several species of Leishmania cause severe, often lethal diseases …

The circadian clock of Arabidopsis thaliana controls many physiological and molecular
processes, allowing plants to anticipate daily changes in their environment. However …