Aspergillus niger has become one of the most important hosts for food enzyme production
due to its unique food safety characteristics and excellent protein secretion systems. A series …

Lignocellulose is a rich and sustainable globally available carbon source and is considered
a prominent alternative raw material for producing biofuels and valuable chemical …

Aspergillus niger was engineered using a gene responsible for citric acid transport, which
has a significant impact on citric acid secretion when overexpressed. The transport gene …

Itaconic acid is an unsaturated dicarbonic acid which has a high potential as a biochemical
building block, because it can be used as a monomer for the production of a plethora of …

Metabolic engineering requires functional genetic tools for easy and quick generation of
multiple pathway variants. A genetic engineering toolbox for A. niger is presented, which …

The production of recombinant proteins is frequently enhanced at the levels of transcription,
codon usage, protein folding and secretion. Overproduction of heterologous proteins …

Filamentous fungi are competitive hosts for the production of drugs, proteins, and chemicals.
However, their utility is limited by screening methods and low throughput. In this work, a …

Biotechnological production of fuels, chemicals and proteins is dependent on efficient
production systems, typically genetically engineered microorganisms. New genome editing …

Itaconic acid is an unsaturated dicarboxylic acid which has a high potential as a biochemical
building block. It can be microbially produced from some Aspergillus species, such as …

Background Trichoderma reesei has extraordinary potential for high-level protein production
at large scales, and it need to be further explored through genetic engineering tools to …