The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

Age-related neurodegenerative diseases have been associated with chronic
neuroinflammation and microglia activation. However, cumulative evidence supports that …

Oligodendrocytes are the myelinating cells of the central nervous system that constitute
about 5 to 10% of the total glial population. These cells are responsible for myelin sheath …

Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …

Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed
to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that …

Nearly a century ago, jaundiced patients were observed to have surprising and
spontaneous remissions from incurable immunologic diseases including rheumatoid …

The buildup of fat in the liver (hepatic steatosis) is the first step in a series of incidents that
may drive hepatic disease. Obesity is the leading cause of nonalcoholic fatty liver disease …

Ursodeoxycholic acid (UDCA) is a steroid bile acid approved for primary biliary cirrhosis
(PBC). UDCA is reported to have “hepato-protective properties”. Yet, UDCA has …

Background Sepsis and jaundice are common conditions in newborns that can lead to brain
damage. Though lipopolysaccharide (LPS) is known to alter the integrity of the blood-brain …