Renal aging: causes and consequences

ED O'Sullivan, J Hughes… - Journal of the American …, 2017 - journals.lww.com
Individuals age> 65 years old are the fastest expanding population demographic throughout
the developed world. Consequently, more aged patients than before are receiving …

The aging kidney: physiological changes

JR Weinstein, S Anderson - Advances in chronic kidney disease, 2010 - Elsevier
Age-associated loss of kidney function has been recognized for decades. With aging, many
subjects exhibit progressive decreases in glomerular filtration rate and renal blood flow, with …

Global, regional, and national burden of mortality associated with short-term temperature variability from 2000–19: a three-stage modelling study

Y Wu, S Li, Q Zhao, B Wen, A Gasparrini… - The Lancet Planetary …, 2022 - thelancet.com
Background Increased mortality risk is associated with short-term temperature variability.
However, to our knowledge, there has been no comprehensive assessment of the …

Aging biology and geriatric clinical pharmacology

AJ McLean, DG Le Couteur - Pharmacological reviews, 2004 - ASPET
Population aging evokes doomsday economic and sociological prognostication, despite a
minority of older people suffering significant dependency and the potential for advances in …

Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions

A Corsonello, C Pedone… - Current medicinal …, 2010 - ingentaconnect.com
Aging is known to be associated with an increased prevalence of multiple chronic diseases,
which frequently causes the use of complex therapeutic regimens. The aging process is …

The aging kidney revisited: a systematic review

D Bolignano, F Mattace-Raso, EJG Sijbrands… - Ageing research …, 2014 - Elsevier
As for the whole human body, the kidney undergoes age-related changes which translate in
an inexorable and progressive decline in renal function. Renal aging is a multifactorial …

[HTML][HTML] The aging kidney

XJ Zhou, D Rakheja, X Yu, R Saxena, ND Vaziri… - Kidney international, 2008 - Elsevier
Renal aging, by itself, is associated with alterations in renal morphology and a decline in
renal function, which is accelerated and/or accentuated by diseases such as diabetes …

Acute kidney injury in older adults

S Anderson, B Eldadah, JB Halter… - Journal of the …, 2011 - journals.lww.com
Aging kidneys undergo structural and functional changes that decrease autoregulatory
capacity and increase susceptibility to acute injury. Acute kidney injury associates with …

Plasma uric acid level and risk for incident hypertension among men

JP Forman, H Choi, GC Curhan - Journal of the American society …, 2007 - journals.lww.com
Several studies have found that uric acid (UA) level is associated with an increased risk for
hypertension, but the association could be confounded by metabolic factors that were not …

The aging kidney: increased susceptibility to nephrotoxicity

X Wang, JV Bonventre, AR Parrish - International journal of molecular …, 2014 - mdpi.com
Three decades have passed since a series of studies indicated that the aging kidney was
characterized by increased susceptibility to nephrotoxic injury. Data from these experimental …