Pathogenesis of antiphospholipid syndrome: understanding the antibodies

PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

Annexins: from structure to function

V Gerke, SE Moss - Physiological reviews, 2002 - journals.physiology.org
Annexins are Ca2+ and phospholipid binding proteins forming an evolutionary conserved
multigene family with members of the family being expressed throughout animal and plant …

Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS

S Chaturvedi, EM Braunstein, X Yuan… - Blood, The Journal …, 2020 - ashpublications.org
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy
morbidity in the presence of antiphospholipid antibodies, including anti-β2-glycoprotein-I …

Epidemiology and the medical causes of miscarriage

L Regan, R Rai - Best practice & research Clinical obstetrics & …, 2000 - Elsevier
Human reproduction is extraordinarily wasteful. The reasons for this have taxed all of the
contributors to this book. As we move into the 21st century it is sobering to reflect on the fact …

Generation, control, and processing of cellular calcium signals

E Carafoli, L Santella, D Branca… - Critical reviews in …, 2001 - Taylor & Francis
Generation, Control, and Processing of Cellular Calcium Signals Page 1 107 1040-9238/01/$.50
© 2001 by CRC Press LLC Critical Reviews in Biochemistry and Molecular Biology, 36(2):107–260 …

Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant

MB Empson, M Lassere, JC Craig… - Cochrane database of …, 2005 - cochranelibrary.com
Background A range of treatments have been proposed to improve pregnancy outcome in
recurrent pregnancy loss associated with antiphospholipid antibody (APL). Small studies …

[HTML][HTML] Complement in the pathophysiology of the antiphospholipid syndrome

S Chaturvedi, RA Brodsky, KR McCrae - Frontiers in immunology, 2019 - frontiersin.org
The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy
morbidity in the presence of antiphospholipid antibodies (aPL). Complement is a system of …

Pregnancy loss in the antiphospholipid-antibody syndrome—a possible thrombogenic mechanism

JH Rand, XX Wu, HAM Andree… - … England Journal of …, 1997 - Mass Medical Soc
Background The mechanisms of vascular thrombosis and pregnancy loss in the
antiphospholipid-antibody syndrome are unknown. Levels of annexin V, a phospholipid …

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial …

JH Rand, XX Wu, AS Quinn, AW Ashton… - Blood, The Journal …, 2010 - ashpublications.org
Abstract Annexin A5 (AnxA5) is a potent anticoagulant protein that crystallizes over
phospholipid bilayers (PLBs), blocking their availability for coagulation reactions …

Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials

M Empson, M Lassere, JC Craig, JR Scott - Obstetrics & Gynecology, 2002 - Elsevier
OBJECTIVE: To explore the effects of interventions given to improve pregnancy outcome in
women with antiphospholipid antibodies. DATA SOURCES: Cochrane Controlled Trials …