[HTML][HTML] Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration
Musculoskeletal disorders represent a major cause of disability and morbidity globally and
result in enormous costs for health and social care systems. Development of cell-based …
result in enormous costs for health and social care systems. Development of cell-based …
25th anniversary article: supramolecular materials for regenerative medicine
J Boekhoven, SI Stupp - Advanced materials, 2014 - Wiley Online Library
In supramolecular materials, molecular building blocks are designed to interact with one
another via non‐covalent interactions in order to create function. This offers the opportunity …
another via non‐covalent interactions in order to create function. This offers the opportunity …
Advancing the cellular and molecular therapy for intervertebral disc disease
The healthy intervertebral disc (IVD) fulfils the essential function of load absorption, while
maintaining multi-axial flexibility of the spine. The interrelated tissues of the IVD, the annulus …
maintaining multi-axial flexibility of the spine. The interrelated tissues of the IVD, the annulus …
Diversity of intervertebral disc cells: phenotype and function
The intervertebral disc (IVD) is a moderately moving joint that is located between the bony
vertebrae and provides flexibility and load transmission throughout the spinal column. The …
vertebrae and provides flexibility and load transmission throughout the spinal column. The …
The effects of dynamic loading on the intervertebral disc
Loading is important to maintain the balance of matrix turnover in the intervertebral disc
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …
(IVD). Daily cyclic diurnal assists in the transport of large soluble factors across the IVD and …
Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical …
Introduction Currently, there is huge research focus on the development of novel cell-based
regeneration and tissue-engineering therapies for the treatment of intervertebral disc …
regeneration and tissue-engineering therapies for the treatment of intervertebral disc …
Intervertebral disk degeneration: the microenvironment and tissue engineering strategies
Y Dou, X Sun, X Ma, X Zhao, Q Yang - Frontiers in bioengineering …, 2021 - frontiersin.org
Intervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is
inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on …
inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on …
[PDF][PDF] Role of hypoxia and growth and differentiation factor-5 on differentiation of human mesenchymal stem cells towards intervertebral nucleus pulposus-like cells
There is evidence that mesenchymal stem cells (MSCs) can differentiate towards an
intervertebral disc (IVD)-like phenotype. We compared the standard chondrogenic protocol …
intervertebral disc (IVD)-like phenotype. We compared the standard chondrogenic protocol …
Lessons learned from intervertebral disc pathophysiology to guide rational design of sequential delivery systems for therapeutic biological factors
Intervertebral disc (IVD) degeneration has been associated with low back pain, which is a
major musculoskeletal disorder and socio-economic problem that affects as many as 600 …
major musculoskeletal disorder and socio-economic problem that affects as many as 600 …
Critical aspects and challenges for intervertebral disc repair and regeneration—Harnessing advances in tissue engineering
Low back pain represents the highest burden of musculoskeletal diseases worldwide and
intervertebral disc degeneration is frequently associated with this painful condition. Even …
intervertebral disc degeneration is frequently associated with this painful condition. Even …