Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Active droplet sorting in microfluidics: a review

HD Xi, H Zheng, W Guo, AM Gañán-Calvo, Y Ai… - Lab on a Chip, 2017 - pubs.rsc.org
The ability to manipulate and sort droplets is a fundamental issue in droplet-based
microfluidics. Various lab-on-a-chip applications can only be realized if droplets are …

Single molecule protein detection with attomolar sensitivity using droplet digital enzyme-linked immunosorbent assay

L Cohen, N Cui, Y Cai, PM Garden, X Li, DA Weitz… - ACS …, 2020 - ACS Publications
Many proteins are present at low concentrations in biological samples, and therefore,
techniques for ultrasensitive protein detection are necessary. To overcome challenges with …

Biological applications of magnetic nanoparticles

M Colombo, S Carregal-Romero, MF Casula… - Chemical Society …, 2012 - pubs.rsc.org
In this review an overview about biological applications of magnetic colloidal nanoparticles
will be given, which comprises their synthesis, characterization, and in vitro and in vivo …

Droplet based microfluidics

R Seemann, M Brinkmann, T Pfohl… - Reports on progress …, 2011 - iopscience.iop.org
Droplet based microfluidics is a rapidly growing interdisciplinary field of research combining
soft matter physics, biochemistry and microsystems engineering. Its applications range from …

High-throughput screening by droplet microfluidics: Perspective into key challenges and future prospects

EM Payne, DA Holland-Moritz, S Sun, RT Kennedy - Lab on a Chip, 2020 - pubs.rsc.org
In two decades of development, impressive strides have been made for automating basic
laboratory operations in droplet-based microfluidics, allowing the emergence of a new form …

Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology

AB Theberge, F Courtois, Y Schaerli… - Angewandte Chemie …, 2010 - Wiley Online Library
Microdroplets in microfluidics offer a great number of opportunities in chemical and
biological research. They provide a compartment in which species or reactions can be …

Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery

CX Zhao - Advanced drug delivery reviews, 2013 - Elsevier
Considerable effort has been directed towards developing novel drug delivery systems.
Microfluidics, capable of generating monodisperse single and multiple emulsion droplets …

Microfluidics for biosynthesizing: from droplets and vesicles to artificial cells

Y Ai, R Xie, J Xiong, Q Liang - Small, 2020 - Wiley Online Library
Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the
subcategories of biomimetic materials, artificial cells are highly significant for multiple …

Latest developments in micro total analysis systems

A Arora, G Simone, GB Salieb-Beugelaar… - Analytical …, 2010 - ACS Publications
The field of micro total analysis systems (μTAS)(1) or lab on a chip (LOC) has extended its
usefulness into many new fields and disciplines spanning basic research to commercial …