Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and
mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein …

Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

Pemphigus vulgaris (PV) is an autoimmune bullous skin disease caused primarily by
autoantibodies (PV-IgG) against the desmosomal adhesion proteins desmoglein (Dsg) 1 …

Desmosomes are cell-cell adhesive organelles with a well-known role in forming strong
intercellular adhesion during embryogenesis and in adult tissues subject to mechanical …

Introduction Pemphigus is an autoantibody driven disease that impairs the barrier function of
the skin and mucosa by disrupting desmosomes and thereby impeding cellular cohesion. It …

Cadherins mediate cell–cell adhesion through a dynamic process that is strongly dependent
on the cellular context and signaling. Cadherin regulation reflects the interplay between …

Desmosomes provide strong intercellular cohesion essential for the integrity of cells and
tissues exposed to continuous mechanical stress. For desmosome assembly, constitutively …

The single pass, transmembrane proteins of the cadherin family have been appreciated as
important proteins that regulate intercellular adhesion. In addition to this critical function …

Desmosomes are adhering junctions present in all cells of simple and complex epithelia.
They are most abundant in cells of tissues subjected to extensive mechanical stress such as …