Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Abstract Disease Overview Chronic myelomonocytic leukemia (CMML) is a clonal
hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes …

Signal transducer and activator of transcription (STAT) proteins compose a family of
transcription factors critical for cancer stem cells (CSCs), and they are involved in …

Chronic myelomonocytic leukemia (CMML) is a myelodysplastic syndrome/
myeloproliferative overlap neoplasm characterized by sustained peripheral blood …

PURPOSE Hydroxyurea (HY) is a reference treatment of advanced myeloproliferative
neoplasms. We conducted a randomized phase III trial comparing decitabine (DAC) and HY …

Simple Summary Myelodysplastic/myeloproliferative (MDS/MPN) neoplasms are blood
disorders characterized by abnormal cell growth and development. These disorders …

Recurrent mutations in RNA splicing proteins and epigenetic regulators contribute to the
development of myelodysplastic syndrome (MDS) and related myeloid neoplasms. In …

Introduction: The prognosis for patients with metastatic and recurrent pediatric
rhabdomyosarcoma (RMS) remains poor. The availability of preclinical models is essential …

RAS pathway mutations, which are present in 30% of patients with chronic myelomonocytic
leukemia (CMML) at diagnosis, confer a high risk of resistance to and progression after …

Introduction The hallmark discovery of hyperactivation of the janus kinase (JAK)-signal
transducer and activator of transcription (STAT) pathway was a sentinel moment in the …