[HTML][HTML] The world of protein acetylation
Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
manifold effects on the protein level as well as on the metabolome level. The acetyl group …
Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases
Recent studies of N-terminal acetylation have identified new N-terminal acetyltransferases
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
(NATs) and expanded the known functions of these enzymes beyond their roles as ribosome …
First things first: vital protein marks by N-terminal acetyltransferases
N-terminal (Nt) acetylation is known to be a highly abundant co-translational protein
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
modification, but the recent discovery of Golgi-and chloroplast-resident N-terminal …
NATs at a glance
Most proteins receive an acetyl group at the N terminus while in their nascency as the result
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N …
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global
scale has remained obscure. Using genome-wide CRISPR knockout screens in human …
scale has remained obscure. Using genome-wide CRISPR knockout screens in human …
Detailed modeling of positive selection improves detection of cancer driver genes
Identifying driver genes from somatic mutations is a central problem in cancer biology.
Existing methods, however, either lack explicit statistical models, or use models based on …
Existing methods, however, either lack explicit statistical models, or use models based on …
[HTML][HTML] Patterns of invasive growth in malignant gliomas—the hippocampus emerges as an invasion-spared brain region
AA Mughal, L Zhang, A Fayzullin, A Server, Y Li, Y Wu… - Neoplasia, 2018 - Elsevier
BACKGROUND: Widespread infiltration of tumor cells into surrounding brain parenchyma is
a hallmark of malignant gliomas, but little data exist on the overall invasion pattern of tumor …
a hallmark of malignant gliomas, but little data exist on the overall invasion pattern of tumor …
Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates
S Grunwald, LVM Hopf, T Bock-Bierbaum… - Nature …, 2020 - nature.com
The heterotrimeric NatC complex, comprising the catalytic Naa30 and the two auxiliary
subunits Naa35 and Naa38, co-translationally acetylates the N-termini of numerous …
subunits Naa35 and Naa38, co-translationally acetylates the N-termini of numerous …
[HTML][HTML] Phenotypic and expressional heterogeneity in the invasive glioma cells
A Fayzullin, CJ Sandberg, M Spreadbury… - Translational …, 2019 - Elsevier
BACKGROUND: Tumor cell invasion is a hallmark of glioblastoma (GBM) and a major
contributing factor for treatment failure, tumor recurrence, and the poor prognosis of GBM …
contributing factor for treatment failure, tumor recurrence, and the poor prognosis of GBM …
N-terminal acetyltransferases are cancer-essential genes prevalently upregulated in tumours
C Koufaris, A Kirmizis - Cancers, 2020 - mdpi.com
Simple Summary Cancer remains one of the leading causes of mortality globally. Ultimately,
cancers are driven by the disruption of normal mechanisms that control the growth and …
cancers are driven by the disruption of normal mechanisms that control the growth and …