MicroRNAs in metabolism and metabolic disorders

V Rottiers, AM Näär - Nature reviews Molecular cell biology, 2012 - nature.com
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example,
miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in …

[HTML][HTML] MicroRNAs in obesity and related metabolic disorders

JF Landrier, A Derghal, L Mounien - Cells, 2019 - mdpi.com
Metabolic disorders are characterized by the inability to properly use and/or store energy.
The burdens of metabolic disease, such as obesity or diabetes, are believed to arise through …

[HTML][HTML] Role of microRNAs in obesity and obesity-related diseases

G Iacomino, A Siani - Genes & nutrition, 2017 - Springer
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been
the object of intensive research. miRNAs have emerged as key mediators of metabolic …

Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance

T Liu, YC Sun, P Cheng, HG Shao - Biochemical and biophysical research …, 2019 - Elsevier
Obesity-associated insulin resistance is a forerunner of type 2 diabetes. Macrophages
reside within adipose tissue (ATMs) have been reported to regulate insulin sensitivity …

Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice

F Dang, Y Jiang, R Pan, Y Zhou, S Wu, R Wang… - Food & Function, 2018 - pubs.rsc.org
Probiotics have been proposed as an option for the prevention of type 2 diabetes mellitus
(T2DM). The objective of this study was to evaluate the hypoglycemic effects of Lactobacillus …

[HTML][HTML] MicroRNAs and metabolism crosstalk in energy homeostasis

O Dumortier, C Hinault, E Van Obberghen - Cell metabolism, 2013 - cell.com
In record time, microRNAs (miRNAs) have acquired the respected stature of important
natural regulators of global gene expression. Multiple studies have demonstrated that a …

[HTML][HTML] Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

B Zhou, C Li, W Qi, Y Zhang, F Zhang, JX Wu, YN Hu… - Diabetologia, 2012 - Springer
Abstract Aims/hypothesis Sirtuin-1 (SIRT1) is a potential therapeutic target to combat insulin
resistance and type 2 diabetes. This study aims to identify a microRNA (miRNA) targeting …

[HTML][HTML] microRNA crosstalk influences epithelial-to-mesenchymal, endothelial-to-mesenchymal, and macrophage-to-mesenchymal transitions in the kidney

SP Srivastava, AF Hedayat, K Kanasaki… - Frontiers in …, 2019 - frontiersin.org
microRNAs (miRNAs) are small, non-coding nucleotides that regulate diverse biological
processes. Altered microRNA biosynthesis or regulation contributes to pathological …

The microRNA-29 family dictates the balance between homeostatic and pathological glucose handling in diabetes and obesity

J Dooley, JE Garcia-Perez, J Sreenivasan… - Diabetes, 2016 - Am Diabetes Assoc
The microRNA-29 (miR-29) family is among the most abundantly expressed microRNA in
the pancreas and liver. Here, we investigated the function of miR-29 in glucose regulation …

Serum miR-29a and miR-122 as potential biomarkers for non-alcoholic fatty liver disease (NAFLD)

K Jampoka, P Muangpaisarn, K Khongnomnan… - Microrna, 2018 - ingentaconnect.com
Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is an over accumulation of
triglyceride in the liver without alcohol consumption. Its major cause is insulin resistance …