Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …

Frontotemporal dementia encompasses a group of clinical syndromes defined
pathologically by degeneration of the frontal and temporal lobes. Historically, these …

While frontotemporal dementia has been considered a neurodegenerative disease that
starts in mid-life or later, it is now clearly established that cortical and subcortical volume loss …

Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

The disease syndromes of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia
(FTD) display considerable clinical, genetic and pathological overlap, yet mounting …

This review offers an in-depth examination of amyotrophic lateral sclerosis (ALS),
addressing its epidemiology, pathophysiology, clinical presentation, diagnostic techniques …

Purpose Neuropathological data suggest that ALS with SOD1 mutations (SOD1-ALS) is a
distinct form of ALS. We evaluated brain metabolic changes characterizing SOD1-ALS as …

The escalating global trend of aging has intensified the focus on health concerns prevalent
among the elderly. Notably, Dementia related diseases, including Alzheimer's disease (AD) …

Amyotrophic lateral sclerosis (ALS) has long been considered to be a purely motor disorder.
However, it has become apparent that many ALS patients develop cognitive and behavioral …