Over the past decades advances in bioengineering and expanded insight in tumor
immunology have resulted in the emergence of novel bispecific antibody (bsAb) constructs …

Innate immune cells are active at the front line of host defense against pathogens and now
appear to play a range of roles under non-infectious conditions as well, most notably in …

Bispecific T cell engagers (bsTCEs) hold great promise for cancer treatment but face
challenges due to the induction of cytokine release syndrome (CRS), on-target off-tumor …

Melanoma-induced suppression of dendritic cells (DC) in the sentinel lymph node (SLN)
interferes with the generation of protective antitumor immunity. In an effort to strengthen …

Natural killer T cells carrying a highly conserved, semi-invariant T cell receptor
(TCR)[invariant natural killer T (iNKT) cells] are a subset of unconventional T lymphocytes …

Abstract Vγ9Vδ2-T cells constitute the predominant subset of γδ-T cells in human peripheral
blood and have been shown to play an important role in antimicrobial and antitumor immune …

Dendritic cells (DCs) are key players in the induction of immune responses. Adoptive
transfer of autologous mature DCs loaded with tumor-associated antigens is a promising …

Natural killer T (NKT) cells are a small population of lymphocytes that possess
characteristics of both innate and adaptive immune cells. They are uniquely poised to …

The liver is one of the most important immunological organs that remains tolerogenic in
homeostasis yet promotes rapid responses to pathogens in the presence of a systemic …

Impaired immune effector functions in the melanoma sentinel lymph node (SLN) may allow
for early metastatic events. In an effort to determine the optimal way to strengthen immune …