Plant secondary metabolites (PSMs) play many roles including defense against pathogens,
pests, and herbivores; response to environmental stresses, and mediating organismal …

Aberrant metabolism is the root cause of several serious health issues, creating a huge
burden to health and leading to diminished life expectancy. A dysregulated metabolism …

Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …

Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …

Systemic vascular inflammation plays multiple maladaptive roles which contribute to the
progression and destabilization of atherosclerotic cardiovascular disease (ASCVD). These …

Humans display remarkable interindividual variation in their immune response to identical
challenges. Yet, our understanding of the genetic and epigenetic factors contributing to such …

The advent of large-scale microbiome studies affords newfound analytical opportunities to
understand how these communities of microbes operate and relate to their environment …

Over the past 15 years, genome-wide association studies (GWASs) have enabled the
systematic identification of genetic loci associated with traits and diseases. However, due to …

Drug discovery is important in cancer therapy and precision medicines. Traditional
approaches of drug discovery are mainly based on in vivo animal experiments and in vitro …

Metabolic processes play a critical role in immune regulation. Metabolomics is the
systematic analysis of small molecules (metabolites) in organisms or biological samples …