Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated
from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic …

The heart utilizes large amounts of fatty acids as energy providing substrates. The
physiological balance of lipid uptake and oxidation prevents accumulation of excess lipids …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

Metabolic sensors such as AMPK and SIRT1, gatekeepers of the activity of the master
regulator of mitochondria, PGC-1α, are vital links in a regulatory network for metabolic …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Aging is the outcome of a balance between damage and repair. The rate of aging and the
appearance of age-related pathology are modulated by stress response and repair …

During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to
lipid as the main energy source to preserve glycogen stores and blood glucose levels for …

AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake …

1704 Circulation Research May 27, 2016 of epigenetic mechanisms contributing to
macrovascular disease in diabetes. The authors highlight the recent identification of …

Significance: Skeletal muscle is a highly plastic tissue. Exercise evokes signaling pathways
that strongly modify myofiber metabolism and physiological and contractile properties of …